Serveur d'exploration sur le patient édenté

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Transcriptional regulation of bone and joint remodeling by NFAT

Identifieur interne : 004F48 ( Main/Exploration ); précédent : 004F47; suivant : 004F49

Transcriptional regulation of bone and joint remodeling by NFAT

Auteurs : Despina Sitara [États-Unis] ; Antonios O. Aliprantis [États-Unis]

Source :

RBID : ISTEX:EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D

English descriptors

Abstract

Summary:  Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture‐prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT‐regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT‐driven cellular responses within this context to inspire future research endeavors.

Url:
DOI: 10.1111/j.0105-2896.2009.00849.x


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Transcriptional regulation of bone and joint remodeling by NFAT</title>
<author>
<name sortKey="Sitara, Despina" sort="Sitara, Despina" uniqKey="Sitara D" first="Despina" last="Sitara">Despina Sitara</name>
</author>
<author>
<name sortKey="Aliprantis, Antonios O" sort="Aliprantis, Antonios O" uniqKey="Aliprantis A" first="Antonios O." last="Aliprantis">Antonios O. Aliprantis</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1111/j.0105-2896.2009.00849.x</idno>
<idno type="url">https://api.istex.fr/document/EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">007509</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">007509</idno>
<idno type="wicri:Area/Istex/Curation">007509</idno>
<idno type="wicri:Area/Istex/Checkpoint">001A50</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A50</idno>
<idno type="wicri:doubleKey">0105-2896:2010:Sitara D:transcriptional:regulation:of</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904911</idno>
<idno type="RBID">PMC:2904911</idno>
<idno type="wicri:Area/Pmc/Corpus">002109</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002109</idno>
<idno type="wicri:Area/Pmc/Curation">002109</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002109</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002296</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002296</idno>
<idno type="wicri:Area/Ncbi/Merge">002C59</idno>
<idno type="wicri:Area/Ncbi/Curation">002C59</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002C59</idno>
<idno type="wicri:doubleKey">0105-2896:2010:Sitara D:transcriptional:regulation:of</idno>
<idno type="wicri:Area/Main/Merge">004F89</idno>
<idno type="wicri:Area/Main/Curation">004F48</idno>
<idno type="wicri:Area/Main/Exploration">004F48</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main">Transcriptional regulation of bone and joint remodeling by NFAT</title>
<author>
<name sortKey="Sitara, Despina" sort="Sitara, Despina" uniqKey="Sitara D" first="Despina" last="Sitara">Despina Sitara</name>
<affiliation wicri:level="2">
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Aliprantis, Antonios O" sort="Aliprantis, Antonios O" uniqKey="Aliprantis A" first="Antonios O." last="Aliprantis">Antonios O. Aliprantis</name>
<affiliation wicri:level="2">
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<country xml:lang="fr" wicri:curation="lc">États-Unis</country>
<wicri:regionArea>Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Arthritis Center, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j" type="main">Immunological Reviews</title>
<title level="j" type="sub">Inflammatory Arthritis</title>
<title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title>
<idno type="ISSN">0105-2896</idno>
<idno type="eISSN">1600-065X</idno>
<imprint>
<biblScope unit="vol">233</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="286">286</biblScope>
<biblScope unit="page" to="300">300</biblScope>
<biblScope unit="page-count">15</biblScope>
<publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="2010-01">2010-01</date>
</imprint>
<idno type="ISSN">0105-2896</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0105-2896</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Acad</term>
<term>Aliprantis</term>
<term>Alkaline phosphatase</term>
<term>Angiogenesis</term>
<term>Anion exchanger</term>
<term>Arthritis</term>
<term>Arthritis rheum</term>
<term>Articular</term>
<term>Articular cartilage</term>
<term>Better understanding</term>
<term>Biochem</term>
<term>Biochem biophys</term>
<term>Biol</term>
<term>Biol chem</term>
<term>Biologic processes</term>
<term>Bone formation</term>
<term>Bone loss</term>
<term>Bone mass</term>
<term>Bone resorption</term>
<term>Bone surface</term>
<term>Calcineurin</term>
<term>Calcineurin inhibitors</term>
<term>Calcineurin nfat axis</term>
<term>Calcineurin nfat pathway</term>
<term>Calcineurin nfats</term>
<term>Cartilage</term>
<term>Cartilage biology</term>
<term>Catabolic</term>
<term>Catabolic enzymes</term>
<term>Catabolic pathways</term>
<term>Chem</term>
<term>Cherubism</term>
<term>Chondrocyte</term>
<term>Chondrocyte proliferation</term>
<term>Chondrocytes</term>
<term>Cytokine</term>
<term>Degradative enzymes</term>
<term>Differentiation</term>
<term>Endothelial</term>
<term>Endothelial cells</term>
<term>Exchanger</term>
<term>Further experimentation</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Genes encoding</term>
<term>Goldring</term>
<term>Growth factor</term>
<term>Hco3</term>
<term>Higher levels</term>
<term>Immune</term>
<term>Immune system</term>
<term>Immunol</term>
<term>John wiley sons</term>
<term>Knockout</term>
<term>Knockout mice</term>
<term>Ligand</term>
<term>Macrophage</term>
<term>Mast cells</term>
<term>Master regulator</term>
<term>Mouse</term>
<term>Mutation</term>
<term>Neuron</term>
<term>Neuropeptides</term>
<term>Nfat</term>
<term>Nfat activation</term>
<term>Nfat family members</term>
<term>Nfat pathway</term>
<term>Nfat proteins</term>
<term>Nfatc1</term>
<term>Nfatc1 expression</term>
<term>Nfatc2</term>
<term>Nfats</term>
<term>Nuclear factor</term>
<term>Nuclear translocation</term>
<term>Osteoarthritis</term>
<term>Osteoblast</term>
<term>Osteoblast differentiation</term>
<term>Osteoclast</term>
<term>Osteoclast differentiation</term>
<term>Osteoclast formation</term>
<term>Osteoclast precursors</term>
<term>Osteoclastogenesis</term>
<term>Osteopetrosis</term>
<term>Osteoporosis</term>
<term>Pathogenesis</term>
<term>Pathway</term>
<term>Peptide</term>
<term>Periarticular</term>
<term>Periarticular bone</term>
<term>Pharmacologic</term>
<term>Pharmacologic inhibition</term>
<term>Phenotype</term>
<term>Phosphatase</term>
<term>Precursor</term>
<term>Proc natl acad</term>
<term>Promoter</term>
<term>Rankl</term>
<term>Receptor</term>
<term>Regulator</term>
<term>Regulatory domain</term>
<term>Resorption</term>
<term>Resorption lacuna</term>
<term>Reviews sitara aliprantis bone</term>
<term>Rheum</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Sitara</term>
<term>Sitara aliprantis bone</term>
<term>Synovial</term>
<term>Synovial angiogenesis</term>
<term>Synoviocytes</term>
<term>Synovium</term>
<term>Takayanagi</term>
<term>Tnfa</term>
<term>Transcription</term>
<term>Transcription factor</term>
<term>Transcriptional</term>
<term>Vegf</term>
<term>Vegf pathway</term>
<term>Vertebrate</term>
<term>Vertebrate body plan</term>
<term>Wildtype</term>
<term>Wildtype mice</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en">
<term>Acad</term>
<term>Aliprantis</term>
<term>Alkaline phosphatase</term>
<term>Angiogenesis</term>
<term>Anion exchanger</term>
<term>Arthritis</term>
<term>Arthritis rheum</term>
<term>Articular</term>
<term>Articular cartilage</term>
<term>Better understanding</term>
<term>Biochem</term>
<term>Biochem biophys</term>
<term>Biol</term>
<term>Biol chem</term>
<term>Biologic processes</term>
<term>Bone formation</term>
<term>Bone loss</term>
<term>Bone mass</term>
<term>Bone resorption</term>
<term>Bone surface</term>
<term>Calcineurin</term>
<term>Calcineurin inhibitors</term>
<term>Calcineurin nfat axis</term>
<term>Calcineurin nfat pathway</term>
<term>Calcineurin nfats</term>
<term>Cartilage</term>
<term>Cartilage biology</term>
<term>Catabolic</term>
<term>Catabolic enzymes</term>
<term>Catabolic pathways</term>
<term>Chem</term>
<term>Cherubism</term>
<term>Chondrocyte</term>
<term>Chondrocyte proliferation</term>
<term>Chondrocytes</term>
<term>Cytokine</term>
<term>Degradative enzymes</term>
<term>Differentiation</term>
<term>Endothelial</term>
<term>Endothelial cells</term>
<term>Exchanger</term>
<term>Further experimentation</term>
<term>Gene</term>
<term>Gene expression</term>
<term>Genes encoding</term>
<term>Goldring</term>
<term>Growth factor</term>
<term>Hco3</term>
<term>Higher levels</term>
<term>Immune</term>
<term>Immune system</term>
<term>Immunol</term>
<term>John wiley sons</term>
<term>Knockout</term>
<term>Knockout mice</term>
<term>Ligand</term>
<term>Macrophage</term>
<term>Mast cells</term>
<term>Master regulator</term>
<term>Mouse</term>
<term>Mutation</term>
<term>Neuron</term>
<term>Neuropeptides</term>
<term>Nfat</term>
<term>Nfat activation</term>
<term>Nfat family members</term>
<term>Nfat pathway</term>
<term>Nfat proteins</term>
<term>Nfatc1</term>
<term>Nfatc1 expression</term>
<term>Nfatc2</term>
<term>Nfats</term>
<term>Nuclear factor</term>
<term>Nuclear translocation</term>
<term>Osteoarthritis</term>
<term>Osteoblast</term>
<term>Osteoblast differentiation</term>
<term>Osteoclast</term>
<term>Osteoclast differentiation</term>
<term>Osteoclast formation</term>
<term>Osteoclast precursors</term>
<term>Osteoclastogenesis</term>
<term>Osteopetrosis</term>
<term>Osteoporosis</term>
<term>Pathogenesis</term>
<term>Pathway</term>
<term>Peptide</term>
<term>Periarticular</term>
<term>Periarticular bone</term>
<term>Pharmacologic</term>
<term>Pharmacologic inhibition</term>
<term>Phenotype</term>
<term>Phosphatase</term>
<term>Precursor</term>
<term>Proc natl acad</term>
<term>Promoter</term>
<term>Rankl</term>
<term>Receptor</term>
<term>Regulator</term>
<term>Regulatory domain</term>
<term>Resorption</term>
<term>Resorption lacuna</term>
<term>Reviews sitara aliprantis bone</term>
<term>Rheum</term>
<term>Rheumatoid</term>
<term>Rheumatoid arthritis</term>
<term>Sitara</term>
<term>Sitara aliprantis bone</term>
<term>Synovial</term>
<term>Synovial angiogenesis</term>
<term>Synoviocytes</term>
<term>Synovium</term>
<term>Takayanagi</term>
<term>Tnfa</term>
<term>Transcription</term>
<term>Transcription factor</term>
<term>Transcriptional</term>
<term>Vegf</term>
<term>Vegf pathway</term>
<term>Vertebrate</term>
<term>Vertebrate body plan</term>
<term>Wildtype</term>
<term>Wildtype mice</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract">Summary:  Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture‐prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT‐regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT‐driven cellular responses within this context to inspire future research endeavors.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Massachusetts</li>
</region>
</list>
<tree>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Sitara, Despina" sort="Sitara, Despina" uniqKey="Sitara D" first="Despina" last="Sitara">Despina Sitara</name>
</region>
<name sortKey="Aliprantis, Antonios O" sort="Aliprantis, Antonios O" uniqKey="Aliprantis A" first="Antonios O." last="Aliprantis">Antonios O. Aliprantis</name>
<name sortKey="Aliprantis, Antonios O" sort="Aliprantis, Antonios O" uniqKey="Aliprantis A" first="Antonios O." last="Aliprantis">Antonios O. Aliprantis</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004F48 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004F48 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:EC49CD2549DD9BB3A2BFFF0ED9D42705BA48F99D
   |texte=   Transcriptional regulation of bone and joint remodeling by NFAT
}}

Wicri

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022